Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation
نویسندگان
چکیده
منابع مشابه
Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation.
Previously, we reported that chronic activation of the estrogen receptor GPR30 by its selective agonist G-1 decreases blood pressure in ovariectomized hypertensive mRen2.Lewis (mRen2) rats but not intact male littermates. Furthermore, G-1 relaxes female mesenteric resistance arteries via both endothelium-dependent and -independent mechanisms. Because of the lack of a blood pressure-lowering eff...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2013
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00649.2012